구강 편평태선에서의 T 림프구 및 랑게르한스 세포의 분포
Immunopathogenesis of Oral Lichen Planus with Respect to the Distribution of CD4+ T Cells, CD8+ T Cells and Langerhans Cells
김수진, 조영아, 윤혜정, 홍성두, 이재일, 홍삼표,
소속 상세정보
김수진 ( Kim Soo-Jin ) - 서울대학교 치의학대학원 구강병리학교실
조영아 ( Cho Yeong-Ah ) - 서울대학교 치의학대학원 구강병리학교실
윤혜정 ( Yoon Hye-Jung ) - 서울대학교 치의학대학원 구강병리학교실
홍성두 ( Hong Seong-Doo ) - 서울대학교 치의학대학원 구강병리학교실
이재일 ( Lee Jae-Il ) - 서울대학교 치의학대학원 구강병리학교실
홍삼표 ( Hong Sam-Pyo ) - 서울대학교 치의학대학원 구강병리학교실
KMID : 0829220120360030179
Abstract
Numerous reports on the immunopathogenesis of an oral lichen planus (OLP) have shown some inconsistency in terms of the role and distribution of CD4+ and CD8+ T cells, and Langerhans cells (LC). This has led to the hypothesis that although the clinical and histopathological manifestations of OLPs appear similar, they can be grouped into CD4+ predominant lesions and CD8+ ones on the varied immunopathogenesis or clinical progress. This study investigated the distribution of CD4+ T cells, CD8+ T cells, LC and the ratio of CD4/CD8 and defined the important immunocompetent cells. In addition, the clinicopathological and histopathological correlation with those immunocompetent cells were investigated. Frozen sections of 16 OLPs and 5 normal buccal mucosae were immunostained. Quantification was done using KAPPA Imagebase software and statistical analysis using SPSS 10.0 statistical package. CD8+ T cells were consistently more abundant in the epithelium of the OLP than CD4+ T cells, but no difference between the two cells was detected in the lamina propria. The intra-epithelial CD4+ T cells revealed a positive linear correlation with the intra-epithelial CD8+ T cells. In the lamina propria, the number of LC had a positive linear correlation with CD4/CD8 ratio. The number of LCs was higher in the reticular type of OLP compared to the erosive type. The histopathological features such as hyperkeratosis, acanthosis, the band-like infiltration of mononuclear cells, and liquefaction degeneration did not show significant correlation with the CD4/CD8 ratio. The results suggest that CD8+ T cells play major role in immunopathogenesis of OLP. The immunopathogenesis of OLP appears to vary from lesion to lesion in relation to the clinical progress.
키워드
CD4+ T cell;CD8+ T cells;Langerhans cell;Oral Lichen Planus;Immunopathogenesis
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